Cut off line in AFP smoothly

Aug 6th, 2022
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How to Cut off line in AFP

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on top of that we have another drug which I would like to hear a little bit of thoughts on but before we go to the talk about trimester of AB I would like to go back to Catherine AFB whats AFB thats a great question if he is is a protein that is released by hepatocellular carcinoma as well as other cancers its been reported in as well as the liver itself when it is injured and regenerating and I explained it to my patients as AFP is a sign of liver cell growth and regeneration so for instance in someone with an acute liver injury we want to see a high AFP to tell us that the liver is trying to heal so it has been shown that patients who have liver cancer with a high AFP are a little bit worse prognosis patients and but we also know its not a perfect test because many liver cancers dont release AFP at all so its its a tool but its only one tool and you cant hang your hat on the whole story with that important introduction lets put it in perspective so Tim back to you but I mi

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Doctors measure AFP in your blood in nanograms per milliliter (ng/mL). The normal level for most healthy adults is between 0 and 8 ng/mL.
Alpha fetoprotein normal range is below ten ng/ml. In the case of adults who arent pregnant, if the results show that there is a high level of AFP, then it indicates that you have liver disease. The AFP levels fluctuate throughout pregnancy. In pregnant women, a higher AFP level indicates Spina bifida in your fetus.
An AFP level between 0 ng/mL to 40 ng/mL is normal for adults. An extremely high level of AFP in your bloodgreater than 400 ng/mLcould be a sign of liver tumors. High levels of AFP may mean other cancers, including Hodgkin disease, lymphoma, and renal cell carcinoma (kidney cancer).
At a cut-off of 20ng/mL, the most commonly used cut-off in clinical practice, AFP has a sensitivity and specificity of approximately 60% and 80% for HCC, respectively(8). However, most studies have assumed that AFP performs equally well in all patients, independent of liver disease etiology or severity.
Here is the normal range: For adults: less than 40 ng/mL. At 15 to 21 weeks gestation: 10 to 150 ng/mL.
Results: Due to the nonnormal distribution of AFP levels, it is useful to relate to reference interval for AFP concentrations at birth that was 15.7-146.5 microg/ml, based on 95% confidence interval (CI). The median value of 48.3 microg/ml is also a useful reference.
Higher than normal AFP levels may mean your baby has an increased risk of having a neural tube defect, such as: Spina bifida, a condition in which the bones of the spine dont close around part of the spinal cord. Anencephaly, a condition in which the brain does not develop properly.
A screen-negative result indicates that the calculated alpha-fetoprotein (AFP) multiple of the median (MoM) falls below the established cutoff of 2.50 MoM.

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