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on top of that we have another drug which I would like to hear a little bit of thoughts on but before we go to the talk about trimester of AB I would like to go back to Catherine AFB whats AFB thats a great question if he is is a protein that is released by hepatocellular carcinoma as well as other cancers its been reported in as well as the liver itself when it is injured and regenerating and I explained it to my patients as AFP is a sign of liver cell growth and regeneration so for instance in someone with an acute liver injury we want to see a high AFP to tell us that the liver is trying to heal so it has been shown that patients who have liver cancer with a high AFP are a little bit worse prognosis patients and but we also know its not a perfect test because many liver cancers dont release AFP at all so its its a tool but its only one tool and you cant hang your hat on the whole story with that important introduction lets put it in perspective so Tim back to you but I mi