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In this video, the speaker discusses the importance of letters of recommendation for applications. They recommend securing 4 to 5 letters, with at least two from science professors, which is considered essential. Additionally, one letter should come from a non-science professor. Recommended sources include a research principal investigator (PI), a physician you've shadowed, and someone from a community or volunteer activity, though these are not mandatory. The key takeaway is to gather letters from individuals who know you well and to build strong relationships with your letter writers, particularly with your research PI, who is likely to have a good understanding of your work.