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Pleural refers to the space between the chest cavity and the lungs, and effusion refers to a collection of fluid, so a pleural effusion is when a disease process causes fluid to start to collect in the pleural space, which can sometimes restrict lung expansion. The pleural cavity or pleural space lies between the parietal pleura which is stuck to the chest wall and the visceral pleura which is stuck to the lungs. Because the lungs fit snugly inside the chest cavity, the visceral and parietal pleura lie right next to each other, and the very very thin space between them contains a layer of fluid that acts as lubrication to allow the lungs to slide back and forth as they expand and contract. This pleural fluid is similar to interstitial fluid and is made slippery by proteins like albumin. Its so similar to interstitial fluid because it--essentially--is interstitial fluid. There is always a tiny bit of plasma that leaks out of capillaries and gets into the interstitial space, and sin
