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i want to share a pretty short story with you all today about some work weamp;#39;ve been doing at calico to explore the intersection of developmental gene programs and aging biology so before jumping into our own work and some of the more recent data i want to take us back historically to the origins of some of the questions weamp;#39;re asking and these really go back to the beginnings of developmental biology when microscopists could first observe xenopus embryos forming speciated cells within an individual organism and that headline question is really whether or not ontogeny can be reversed or whether or not itamp;#39;s a one-way street and i think some of the best evidence and one of the most important experiments honestly in the whole of developmental biology and also aging biology addressed this question pretty directly way back 70 years ago this was performed by a man named john gurdon and what he did was he took one of these embryos on the left here one of these xen
