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so the technology we use at Hudson alpha to study these tumors is to apply a microarray technology to identify parts of the genome that have been lost or gained in a tumor so these are mutations that where large segments of chromosomes have been amplified or deleted through sub mutational mechanism in the tumor cells themselves and those copy number variants the copy number aberrations affect gene function so if a gene has been amplified obviously its doing a lot more than it would have done if it was present in only two copies and that can give the tumor the potential to grow faster and overcome chemo therapeutic treatments so identifying the copy number variants the gains and losses in different genes across the genome can give us a signature of different subclasses of ovarian cancer and what identified drugs that they may or may not be resistant to you