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thank Sony and and Sohail for the invitation Im gonna try to go through some very practical approaches for working with cancer genome sequencing data to produce copy number estimation Im gonna start with a general overview with some quick intro slides a little bit of background a small discussion about weed counting and then discuss a couple of use cases and then finally well get to the data with some with a demo so I usually like to start talks with like like this with an overview of what we can see how we view a cancer genome and until about 1993 this was our new our high resolution view even of the cancer genome 1993 started with CGH and sky on on chromosomes fish as well and has progressed with the sequencing of the human genome weve progressed to the deployment where we can actually measure cellular processes in the cell on a high throughput in a high-throughput way for pretty much every step of the of the central dogma starting with DNA replication and right down through to p