Copy number in a Peer Review Report - Online Editor

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What is an example of a copy number variant?

One of the most well-known examples of a disease-causing CNV is Huntington disease, which is caused by a repeating sequence of three base pairs (known as a trinucleotide repeat) at the end of the coding region of the HTT gene.

What is copy number gain and loss?

CNVs are divided into two major groups: copy number loss (CNL) and copy number gain (CNG). CNL denotes the decreased gene (or sequence fragment) copies in the genome while CNG denotes the gain of additional gene copies in the human genome. Concordance of copy number loss and down-regulation of tumor nih.gov articles PMC5001246 nih.gov articles PMC5001246

What are the types of copy number?

Copy number variations can be generally categorized into two main groups: short repeats and long repeats. However, there are no clear boundaries between the two groups and the classification depends on the nature of the loci of interest.

What does copy number loss mean?

CNL denotes the decreased gene (or sequence fragment) copies in the genome while CNG denotes the gain of additional gene copies in the human genome.

What is the meaning of copy number?

noun. : a numeral placed on a book to distinguish it from other copies of the same title.

What does copy number tell you?

Copy number variation (CNV) is a general term used to describe a molecular phenomenon in which sequences of the genome are repeated, and the number of repeats varies between individuals of the same species.

What is the copy number signature?

Copy number signatures (CN Signatures) are the latest addition to COSMIC Mutational Signatures, a reference database of characteristic combinations of mutation types arising from specific mutagenesis processes.

What is copy number in cancer?

Copy number variation (CNV) is one of the major forms of genetic alterations in cancer. It can affect the gene expression levels through dosage effects. Since CNV is much stable than gene expression, it can be a more robust and better biomarker than gene expression signatures, which can be easily disturbed. Copy Number Variation - an overview | ScienceDirect Topics sciencedirect.com medicine-and-dentistry sciencedirect.com medicine-and-dentistry

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Copy number in the Peer Review Report

Copy number in Peer Review Report – work smarter with DocHub

Follow these easy steps to copy number in Peer Review Report with DocHub:

PDF editing simplified with DocHub

Drive efficiency with the DocHub add-on for Google Workspace

Got questions?