Copy number in the Model Contract

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Aug 6th, 2022
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How to copy number in the Model Contract

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[Music] okay friends uh in this video Im going to discuss about uh the way or the typical mechanism of controlling the copy number of a plasmid now there are several different ways but this is one of the way of controlling the copy number in plasmid cells because the plasmid copy number regulation is really really important because the cell need to regulate the plasmid number at different times of their life cycle different times of their importance that for example a bacterial cell when it start to invade into uh some some host cell uh for the defense and all the mechanism they need to produce lot lot more amount of this plasmid and sometimes when they present in the dormant situations they need to uh lower down the plasmid production procedures thats why they need to control the amount of plasmid which are being produced and the number of plasmid uh to be really uh in in in in regulation okay now in this case we are talking about a mechanism of RNA interference uh for controlling o

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To determine copy number, a relative quantitation analysis is performed between the unknown sample and a calibrator sample (one in which the copy number of the target gene is known).
: a numeral placed on a book to distinguish it from other copies of the same title.
Copy number alterations (CNAs) are somatic changes to chromosome structure that result in gain or loss in copies of sections of DNA, and are prevalent in many types of cancer (2).
One of the most well-known examples of a disease-causing CNV is Huntington disease, which is caused by a repeating sequence of three base pairs (known as a trinucleotide repeat) at the end of the coding region of the HTT gene.
Typically, CNV refers to germline events, which are variants in the population. CNA usually refers to somatic events, like those found in tumors. They are sometimes used interchangeably.
Copy number variation, CNV. Changes in the number of copies of small sections of our genomes can have big consequences. One interesting example is a gene called amylase. This gene is important for digesting starchy foods like potatoes or grains.

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