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foreign presenting to you a few different examples of how we can use Nexus copy number in sort of a case review format before we begin I just want to give a very brief overview this is a typical workflow that you would use for copy number analysis with Nexus first you would take your raw data for pre-processing array platform this includes appymetrics Agilent alumina and also we can get copy number information from your exome or genome sequencing data from here this raw data is interpreted we get the log ratio value and then the segmentation to determine the copy number changes at this point we can also integrate the co-visualization of any sequence variation you may have from XM sequencing genome sequencing or targeted sequencing at this point were going to identify regions of change genes within those regions and possibly some functional information at the level of the regions or genes that are altered we can also query for uh clear these aberrations for anything of Interest we can