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[MUSIC] Welcome and good evening. My name is Anthony Magit. Im the Medical Director of the Office of IRB administration, UC San Diego with responsibility for oversight of human subjects research and also by training a pediatric otolaryngologist, thats a head and neck surgeon. The perspective I bring is from a regulatory ethical perspective from IRBs, which Ill talk a little bit about, about why we have IRBs and how they protect individuals and really lay the foundation for how complex consent is in genomic research, in genetic clinical results as well as research because how dynamic the field is in trying to describe a tremendous body of knowledge, both to providers, care providers, as well as patients and subjects in research settings. Why have an IRB? If you talk to any investigator they wish you probably didnt have an IRB. Its always looked at it as more of a challenge as hoops to jump through before somebody can conduct research involving human subjects. But really is integral