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good afternoon this afternoon our webcast we were going to discuss the results of paradigm hf a clinical trial of an innovative approach to the treatment of symptomatic heart failure with reduced ejection fraction which we often abbreviate as heifer f it is referred to and this new approach is referred to as an angiotensin receptor Knepp releasing inhibitor the article is actually presented as the main results in the New England Journal of Medicine at any GM org it was actually put online yesterday this webcast is being co-sponsored by the European Society of Cardiology and the New England Journal of Medicine my name is Mariell Jessup and Im from the University of Pennsylvania and Ill be the moderator of this unruly bunch of men of but they are distinguished international experts in heart failure first we have the two co-principal investigators of the paradigm hf trial professor John McMurray from the University of Glasgow and dr. Milton Packer from the University of Texas Southwest