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In this tutorial, the instructor demonstrates a method to significantly reduce an Excel file's size by more than 50% without using macros. The key point is to save the file as an Excel binary workbook, which is different and unique compared to using macros. The original file size shown is 8.25 MB, containing around 37,937 line items. By selecting the Excel binary workbook format during the save process, the file size can be reduced effectively. This method is quick and easy to implement, making it a valuable technique for managing large Excel files.