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Monkeypox, an old virus resurfacing in recent reports, was first discovered in 1958 during outbreaks among monkeys used for research. By the 1970s, it began infecting humans in Central and Western Africa, identified as a zoonotic disease that transmits from animals to humans. It is caused by a virus from the orthopoxvirus genus, notable for its oval shape, and is related to smallpox and cowpox viruses. Though initially found in monkeys, monkeypox can also be present in other animals, particularly rodents.