Clear up motif in ASC

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What is ASC in inflammation?

Apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) is a 22 kDa protein that functions as the central adaptor for inflammasome assembly.

What is the structure of ASC?

Structure of human ASC: ASC contains a pyrin domain and a CARD domain. Each domain has 6 helices. The start and the end of each helix are mentioned in the figure along with the starting and ending residue (PDB: 2KN6)

What is the function of the ASC gene?

Results suggest that apoptosis-associated speck-like protein (ASC) can function as an adaptor molecule for Bax and regulate a p53-Bax mitochondrial pathway of apoptosis. Methylation-mediated silencing of TMS1/ASC confers a survival advantage to ovarian tumor cells.

What is ASC in cell?

ASC are often referred to as adipose tissue derived stem cells (ASC or AdMSC) or mesenchymal stem cells (MSC), inferring their suitability for a wide range of regenerative applications.

What does ASC mean stem cell?

Adipose-derived stem cells (ASCs) are pluripotent progenitor cells isolated from the stromal vascular components of adipose tissue. From: Sexual Medicine Reviews, 2020.

What is ASC in immunology?

Apoptosis associated speck like protein containing CARD (ASC) is widely researched and recognized as an adaptor protein participating in inflammasome assembly and pyroptosis. It contains a bipartite structure comprising of a pyrin and a caspase recruitment domain (CARD) domain.

What does ASC mean immunology?

Apoptosis-associated speck-like protein containing a CARD (ASC) has a pivotal role in inflammasome assembly and activation. While ASC function has been primarily implicated in innate immune cells, its contribution to lymphocyte biology is unclear.

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