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so as Laura said habit of color is tasked with maximum sensitivity we want to make sure that every variant or every possibility of a variant is emitted by HEPA type of color and then the idea that we that we use is a very sensitive calling and then filtering separately and the one of the reasons is that different people have different use cases and the clinical use case could be very very different than a research use case so weamp;#39;ve had you know different groups say oh you know as false positive is a lot more expensive to us than a false negative and then other groups say oh no a false negative is much more expensive to us and a false positive and depending on where you lie on that spectrum theyamp;#39;re doing the cost of false positives and false negative you might want to filter differently so here we are in the map we have our raw variant their unfiltered and now we want to filter them and it should be clear that filtering happens at the variant level meaning every row of t
