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so now iamp;#39;m going to talk about bead based sample cleanups so many protocols use these magnetic beads theyamp;#39;re known as ampure or spry beads and what they do is they allow you to clean up dna without binding to a column these can all be done in the same tubes that youamp;#39;re preparing your samples in and you use a magnetic stand to help move those beads to the side instead of using a centrifuge and these beads take advantage of the fact that nucleic acids can be precipitated by polyethylene glycol a polymer and salt and again some of the advantages here is that it doesnamp;#39;t require a column or centrifuge to do the cleanup and so itamp;#39;s really amenable to working with multi-channel pipettes or even liquid handlers that can handle 96 or 384 samples at a time and the other advantage is that by adjusting concentration of salts and polyethylene glycol you can actually isolate specific sizes of nucleic acid which has advantages and this is based off some