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a simple replacement of the standard plate carrier to the vacuum plate carrier is all thatamp;#39;s needed to switch from standard applications to filtration protocols the hydroflex vacuum filtration option is the automated solution for high as well as gentle vacuum filtration to waste protocols it offers a broad and tunable vacuum range from -50 to - 850 MB and is the perfect choice for filtration applications the vacuum status is monitored online and only has to be prepared once protocols for PCR cleanup as well as bead separation are started automatically the plate is self sealing and ventilated again after the filtration step vacuum level is kept constant while the DNA fragments are collected on the Plateamp;#39;s filter filtration dispense and wash steps can be combined and repeated as needed specially developed drop trays help to keep the filtrated plate dry and make manual preparation a thing of the past