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cleaning is something we all understand because we all do it at home or at work we use detergents and disinfectants then apply an appropriate amount of elbow grease and assume that the cleaning process has cleaned clean normally the effectiveness of virtually all cleaning whether domestic or industrial is assessed visually manufacturing areas based on the equipment does it mean to remove previous products and other contaminants to prevent cross-contamination that is where one substance or product contaminates another in an ideal world the cleaning process would be completely effective and everything thatamp;#39;s been cleaned left without any residual contamination either viable or non-viable in practice this is difficult to achieve not least because there are physical limits to the removal of very small often molecular sized particles no less relevant so validation must prove that cleaning will have neutralized or removed all traces of possible contaminants including the detergents a