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[Music] compounding sterile preparations requires a pristine work area compounding personnel must clean and disinfect primary engineering controls some facility cleaning may be done by trained housekeeping personnel but compounding personnel must know how to clean and disinfect every surface of the sterile compounding area lets distinguish between cleaning and disinfecting cleaning removes visible solids or soiling before disinfecting after cleaning disinfecting removes microbial contamination primary engineering controls must be cleaned and disinfected at the beginning of each shift before each batch at least every 30 minutes during compounding and when surfaces are visibly soiled also when surface contamination is known or even suspected to clean an area remove items then clean surfaces by removing loose material and any residue from spills for water-soluble residue use sterile water to clean the surface after cleaning wipe the surface with sterile 70% isopropyl alcohol or a similar