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so as you know that the cleaning validation is one of the cgmp requirement and in case if you have a multi-product manufacturing site then you must conduct the cleaning validation to demonstrate that your processes are capable to limit or control the carryover of previous product into the next product so just assume that you have a multi-product facility and let us say you have six different products to be manufactured in the same facility so ideally you must conduct clinic validation for all these six products and which can be a time consuming and costly affair so to save time money and resources the bracketing approach such as the most difficult to clean at the lowest limit can be used the objective of the most effective to clean at the lowest limit approach is to demonstrate that it has a scientific rational for defining the worst case rating of the substances under investigation defining the worst case rating is going to be very important factor when i talk about difficult to clea