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we get our history of the cleaning validation so how the clinic validation has take start people started taking it very seriously and if you look back into the athletic validation you will find the history going back to 1988. that doesnt mean that the cleaning requirement never exists before that because as a part of cgmp requirement the cleaning validation uh though people do not talk in the terms of the cleaning validation but the usage of the cleaning equipment our equipment cleaning is always the part of the good manufacturing practices but the real the turn you know has occurred in the 1988 when there is a one there was a very important medication to to lower the cholesterol level that is the cholesterol residue USB which was manufactured by the Bristol and the brand name of this product was the question powder so this was the medication you know uh which was that time uh taken almost by 150 000 U.S citizens and it was supposed to be take around five times a day so that was the
