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Health Technology Assessments (HTAs) systematically evaluate the clinical, economic, and social implications of healthcare technologies, such as drugs and medical devices. They inform decision-making regarding the adoption and use of these technologies. HTA involves reviewing evidence related to safety, efficacy, and cost-effectiveness, while also considering patient outcomes, ethical concerns, social implications, and feasibility of implementation. Various stakeholders, including policymakers, healthcare providers, and patients, utilize HTAs to make informed decisions. This video tutorial is sponsored by Nested Knowledge, a platform that supports systematic literature reviews and meta-analyses.