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In America, blood is a lucrative industry worth $3.3 billion in 2021, with centers nationwide. Human blood has no substitute, leading to sporadic shortages that could be life-threatening. There are efforts to lift the ban on gay men donating blood. Major players like Grifols, CSL Plasma, Takeda's BioLife, and Octapharma collect blood, particularly plasma, with donors compensated. Plasma is used for therapies by pharmaceutical companies.