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welcome to another MedCram lecture were going to talk about cephalosporins and specifically the different generations some representative antibiotics in each class and what are the unique things about those generations and what they do in their coverage so there are five generations of cephalosporins weve got the first generation cephalosporin weve got the second which well talk about the third which is the workhorse of the pneumonia scene weve got the fourth generation which has got the Pseudomonas coverage so also in the third and then finally the fifth which is an interesting generation that well talk about as we go from first the second to third to fourth youll see that there is better and better gram-negative coverage so at the very beginning with the first generation cephalosporins we have medications like and and these antibiotics really have no anaerobic coverage so no an aerobic coverage but what they did have a lot of coverage for is gram-positive