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In this tutorial, we will discuss cephalosporins and their different generations, representative antibiotics, unique characteristics, and coverage. There are five generations of cephalosporins: the first generation lacks anaerobic coverage but has good gram-positive coverage, the second generation, the third generation is important for pneumonia, the fourth generation has Pseudomonas coverage, and the fifth generation is unique. Each generation has improved gram-negative coverage compared to the previous one.