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The video tutorial on medication administration emphasizes the importance of thorough validation and checks before administering medication. It highlights the need to ensure accuracy and completeness by comparing the medication administration record (MAR) to the prescriber's orders. The six rights of medication administration—patient, medication, dose, time and frequency, documentation, and route—should be performed during each of the three medication checks. Key steps include checking expiration dates, ensuring patient privacy, verifying identification and allergy status, and conducting relevant assessments. Additionally, it's important to label medications properly, explain their purpose, educate patients about possible side effects, and address any questions they may have.