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In America, the blood industry is a multibillion-dollar sector, valued at $3.3 billion in 2021, with over 2% of U.S. exports consisting of American blood. Due to the lack of substitutes for human blood, maintaining supply is challenging, with current levels at only a one-day supply, leading to potential shortages that can have life-threatening consequences. The industry faces hurdles, such as the FDA's historical ban on blood donations from gay men, which may soon change as studies challenge the ban's scientific basis. Major companies in blood collection include Grifols, CSL Plasma, Takeda’s BioLife, and Octapharma, where donors are compensated, and plasma is used for therapeutics by large pharmaceutical firms.