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[Music] so h718 is an oral oral investigational drug it works by modulating a receptor in the brain called the nmda receptor and it modulates that receptor through positive allosteric modulation in Huntingtons disease and also a number of different neurodegenerative diseases we see changes in nmda functioning and in Huntingtons in particular we see that changes in this functioning correlate or track with changes in cognition and so the idea with sage 718 is perhaps that by restoring aberrant or abnormal nmda tone you may be actually able to improve cognitive impairment early in Huntingtons and therefore have some meaningful effects for patients there is a lot of data to support this therapeutic hypothesis and that includes both pre-clinical translational as well as clinical data so on the translational side one of the benefits of working in the Huntington space is that there are very well established databases of patient data patients who are followed for a number of years non-inter