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In this video tutorial, the presenter explains how to make changes to a purchase order in SAP. First, access the main screen and enter the transaction code ME22N, which opens the purchase order display view. Click on the option for "other purchase order number" to input your specific purchase order number. Once entered, use the spectacles and pen icon to open the purchase order in editable mode. The tutorial emphasizes that after saving the purchase order, you cannot change the vendor, payment terms, or make significant alterations, but you can modify prices, delivery rates, conditions, and some text elements.