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[Music] the overall goal of the following experiment is to utilize the density of mapped reed positions from chromatin immunoprecipitation sequencing data to estimate the posterior mean read density across the genome this is achieved by pre-processing the mapped chip seek reads into blocked density profiles with the same number of reads falling within 200 base pair non-overlapping bins any adjacent bins with the same density are merged into a larger block as a second step posterior mean densities of each block are calculated recursively within the context of all surrounding blocks using a bayesian model with forward and backward filters where the read count for a block is modeled with a poisson distribution with a theta parameter that takes on a gamma-prior distribution with alpha and beta parameters next posterior mean density estimates of each block are evaluated for significance based on whether or not it exceeds the 90th quantile with respect to the input control background densit