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Wilson Tang, the research director for heart failure and cardiac transplant medicine at the Cleveland Clinic, is joined by colleagues Dr. Sanjeev Bhattacharya and Dr. Pavinbach to discuss heart failure with preserved ejection fraction (HFpEF). Initially thought to be related to diastolic dysfunction, HFpEF is now understood to involve elevated pressures in the heart. This can be missed by standard screening tests like echocardiograms or BNP levels. The discrepancy between symptoms and echo findings makes diagnosing and managing HFpEF challenging.