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The tutorial explains how to make changes to a purchase order in SAP. First, access the main screen and enter the transaction code ME22N, then press enter to open the purchase order display view. Click on the "Other Purchase Order" button and input your purchase order number, then press enter. Select the spectacles and pen icon to open the PO in editable mode. Note that after saving, you cannot change the vendor, payment terms, or make significant alterations. Approved changes include the price, delivery rates, conditions, and minor text modifications.
