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In this video tutorial, the presenter explains how to make changes to a purchase order in SAP. The process begins on the main screen, where users enter the transaction code "ME22N" and press enter to open the purchase order display view. Afterward, by clicking the "Other Purchase Order Number" button and entering the desired purchase order number, the editable view can be accessed. It is important to note that while users can modify prices, delivery rates, and some text elements, they cannot change the vendor or payment terms once the purchase order is saved. Only minor adjustments are permitted after saving.