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In this video tutorial, the presenter explains how to modify a purchase order in SAP. To begin, access the main screen and enter the transaction code ME22N, then press enter. A purchase order display view will open. Click the button for "Other Purchase Order Number" and enter your specific purchase order number. After that, click the spectacles and pen icon to open the purchase order in editable mode. It is important to note that once the purchase order is saved, the vendor cannot be changed. However, modifications to price, delivery rates, certain text, and minor details are permissible, while payment terms remain unchanged.