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Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), encompasses neurological disorders affecting motor neurons in the brain and spinal cord. While the precise causes remain unclear, contributing factors may include genetics, age, lifestyle, environmental elements, and neuroinflammation. The prognosis for MND varies based on the disease type, progression, age of onset, and patient health. Although there is currently no cure, risk reduction measures such as regular exercise, avoiding toxins, maintaining a healthy diet, quitting smoking, and ensuring adequate sleep are recommended. Ongoing research into MND includes gene therapy, stem cell therapy, neuroprotective drugs, and assistive technology, yielding promising results.