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[Music] polycythemia vera and essential thrombocythemia are the other sort of common mpns and they transform to myelofibrosis once the disease transforms to primary myelofibrosis even if theyve had polycythemia or theyve had et they become more like a primary myelofibrosis patient where the overall survival is decreased and their risk of developing acute leukemia is greater the only possibility for cure in those patients is a bone marrow transplant [Music]