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Hi. Its Mr. Andersen and welcome to biology essentials video 39. This is how changes in signal transduction pathways can have huge effects. So Im going to talk about poisons and diseases. But I wanted to start with one of the most dangerous animals that we have on our planet. Its the California Newt. California Newt you could pick it up. You could hold it. Its no big deal. But if you were to eat it, you would die just within a few hours. And thats because the California Newt produces a toxin on its skin. We use to think the newt produced it but we now know that its a symbiotic bacteria thats producing this toxin. Its called tetrodotoxin. Its one of the nastiest neurotoxins that weve ever found. It effects the sodium ion channels in the nerves. And so what it does is shuts them down. Our nerves cant work correctly. So those cells dont work. And then we cant breathe and we die as a result of that. Tetrodotoxin is found in lots of other animals. So puffer fish, if yo