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In this video, Mr. Andersen discusses how changes in signal transduction pathways can have significant effects, focusing on poisons and diseases. He starts by mentioning the California Newt, which produces a toxin called tetrodotoxin on its skin. This toxin, produced by symbiotic bacteria, affects sodium ion channels in nerves, leading to nerve dysfunction and ultimately death if ingested. Tetrodotoxin is also found in other animals like puffer fish.