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The cancer cell DNA can tell us a lot about what is driving the tumor and what types of therapies might be successful to fight it. With the new advances in DNA sequencing, we now have a vast amount of information about the DNA sequence of tumor cells. This can be powerful to find changes in tumor cells that are absent in normal cells, including copy number changes, mutations, changes in gene expression and methylation. This information can then be used to identify cancer-driver mutations, discover new molecular targets for therapy, and identify molecular profiles that are associated with a particular clinical outcome. All of this is very powerful, however, this information can sometimes be buried in all of the sequencing results and very hard to visualize. To address this important problem, a group of scientists led by Marco Marra of the Michael Smith Genome Sciences Center has developed a tool called Circos for comparative genomics (to compare multiple sets of sequencing data). Befor