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A food allergy is a medical condition characterized by an abnormal immune response to certain foods. The most common allergens are known as the "big eight," which include milk, eggs, peanuts, tree nuts, seafood, shellfish, soy, and wheat. Normally, food does not trigger allergy responses due to a process called oral tolerance. This process involves food traveling through the stomach and intestines, where gastric acids and proteases break down proteins into small fragments called oligopeptides. These oligopeptides interact with Peyer's patches, tissues along the intestinal wall containing M cells, which play a role in immune response regulation.
