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A paper published in Current Biology has confirmed the importance of the 5-HT2A receptor for LSD. Part of the paper looked at the drugamp;#39;s subjective effects, especially on the generation of personal meaning. The pharmacological side of the study involved LSD and ketanserin, a 5-HT2A antagonist. Participants were given questionnaires to measure the subjective effects. They were also studied using fMRI to measure LSDamp;#39;s impact on different regions of the brain. All of the core subjective effects were measured, but the study had a specific focus on measures of personal meaning and relevance. To study this, they used music that was designated as meaningful, neutral, or meaningless for each participant. They then measured how LSD changed the impact of the music. In a double-blind, randomized, crossover style, participants experienced three conditions. Placebo Placebo followed by LSD And Ketanserin followed by LSD 100 micrograms of LSD and 40 mg of ketanserin were used. The tri
