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does minoxidil work for hair loss the short answer is yes heres how minoxidil is a pro drug an inactive form of medication it is then converted into the active form which is called minoxidil sulfate this conversion is done by an enzyme called sulfotransferase enzyme that enzyme is expressed in the outer root sheath of hair follicles the higher the enzyme activity in the person the better the response to Minoxidil check out the full video of minoxidil which is live on our Channel