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In America, blood is a big business worth billions of dollars, with centers across the country. The North American blood market was valued at $3.3 billion in 2021, making up over 2% of U.S. exports. Human blood has no substitute, leading to sporadic shortages with potential life or death consequences. Despite being a valuable public health resource, hurdles remain for some groups, including gay men who face a ban on donating blood. Major players in blood collection, such as Grifols and CSL Plasma, compensate donors and provide plasma for therapies by pharmaceutical companies.