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[Music] and we know that spots in the brain are common and thats kind of why people get misdiagnosed and so what were proposing is the use of the central vein sign as tool that will improve the specificity of the diagnostic criteria incorporate into the diagnostic criteria and retain the sensitivity and so the idea here is that the majority of lesions in ms have a small vein that goes through the middle of them and weve developed technology and weve done this in collaboration with National Institutes of Health with viscosity weve developed a technique that enables us to image those small vessels inside of lesions and so we know from previous studies that patients who have migraines and they have small spots or people who are vascular disease and they have small spots you actually cant see veins or you can see veins in only a small proportion of those lesions versus an MS its kind of more than 90% of the lesions will have the central vein so what were going to be talking about