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I grew up to study the brain because I have a brother who has been diagnosed with a brain disorder, schizophrenia. And as a sister and later, as a scientist, I wanted to understand, why is it that I can take my dreams, I can connect them to my reality, and I can make my dreams come true? What is it about my brothers brain and his schizophrenia that he cannot connect his dreams to a common and shared reality, so they instead become delusion? So I dedicated my career to research into the severe mental illnesses. And I moved from my home state of Indiana to Boston, where I was working in the lab of Dr. Francine Benes, in the Harvard Department of Psychiatry. And in the lab, we were asking the question, What are the biological differences between the brains of individuals who would be diagnosed as normal control, as compared with the brains of individuals diagnosed with schizophrenia, schizoaffective or bipolar disorder? So we were essentially mapping the microcircuitry of the brain: w