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good morning um i have nothing to declare so in a typical fmri experiment were going to administer some type of stimulus to our participant or assume that theres some undergo underlying stimulus in the resting state that this activity in neuronal activity is going to be somehow coupled to a local vascular response and this vascular or hemodynamic response is what we can then detect with an fmri secret sequence as described eloquently in the previous talk so our stimulus is going to have some paradigm timing this is an example of a block design and as well hear later in the sessions you then model what you think this hemodynamic response is going to be and you look for any signals that appear like that paradigm in your fmri data however its really important that we always keep in mind that the fmri signals are never a direct measure of that neuronal activity at least in a typical acquisition and we need to understand this coupling between neuronal activity and this hemodynamic resp