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hello this is Spencer Hoover and Iamp;#39;m giving this presentation in context of the Minnesota workshop 2019 at CMRR in November and I want to talk about lay a dependent fMRI specifically lay dependent fMRI with sequences that are sensitive to cerebral blood volume changes and as it has been shown a lot in the literature already itamp;#39;s not so straightforward to reliably measure their dependent FM right the MRI method needs many many quality measures to be fulfilled while there have been a lot of advancements in the recent years to make laid in an fMRI more sensitive more specific have a larger coverage faster acquisition and very high resolution itamp;#39;s not so straightforward to achieve all of these features at the same time so this presentation I want to talk about our approaches to push as many of these pentagonal model and sequence parameters here at the same time and I would like to talk about specificity and sensitivity first because those are some of the most import