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hello and welcome to this video my name is bhaskar napday and today we are going to talk about how one can calculate this similarity factor that is f2 to prove that the two dissolution profiles are similar now the f2 calculation can be used in case of availing the biowaver in case if your drug substance belongs to bcs class 1 or the f2 also can be used to get the bioware for the subsequent strength provided your formulation is dose proportionate lepto can also be used during the justification of the similarities of the drug product performance post approval of any changes so let us begin with the presentation and this presentation is based on to the guidelines given by the uh emma you know and the name of the guideline is what the guideline on the investigation of bio equivalence so these are the three important points that we are going to discuss today the first one is inhibitor dissolution in support of biowaver so how the in vitro release can help you in getting the bi waiver so wha