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what id like to do over the next couple of minutes is provide you with the immunological basis that would support a third booster mrna immunization i will make four points and show you representative data from each of these first antibody levels decline over time second higher levels of antibody are associated with higher levels of efficacy of the vaccine third higher levels of antibody may be required to protect against the problematic delta variant and finally a boost to mrna immunization increases antibody titers by at least tenfold and likely much more next slide so lets take the first concept that antibody levels decline over time in this case following two mrna immunizations and thats regardless of the varying so if you look at the horizontal axis at day 29 is when you get your second shot you can see the level of antibodies go up at 43 days but look what happens at 119 and 209 days regardless of the variant involved the antibody levels against those variants decline over time
