Blot pecularity in 602

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How to blot pecularity in 602

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today weamp;#39;re dispensing some bioptic lenses to larry thereamp;#39;s a decreased vision due to mac and regeneration uh first of all larry we got you a desktop reading device uh a few weeks ago howamp;#39;s that working out for you thatamp;#39;s great i really appreciate that it helps with the mail and magazines and anything like that i use it a lot because with that we can actually change the magnification make it larger or smaller for you we could also change the background contrast you can see colors you read magazines things like that the different things i use at different settings yeah and with these glasses howamp;#39;s helping you with your distance there itamp;#39;s great it uh it allows me to read quite a bit smaller stuff you know when we went out in the hallway and looked down the hall and out the window howamp;#39;d that seem clear much clearer than what iamp;#39;ve been used to they also have these caps for you and what that will do is weamp;#

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What is BRAF structure and function?

BRAF is an effector kinase that functions downstream of RAS and propagates this oncogenic activity through MEK and ERK. Across cancers, BRAF alterations include gain-of-function mutations, copy-number alterations, and structural rearrangements.

What type of protein is BRAF?

B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion.

What is the structure of BRAF?

The BRAF kinase domain adopts a bilobal structure (named as small lobe and large lobe) which is separated by a catalytic cleft (Fig. 1). An aspartic acid residue in the N-region of the BRAF protein stabilizes its small lobe [4,1214].

What does BRAF bind to?

Wild-type BRAF binds to CRAF in a RAS-dependent manner and although this binding is weak, it leads to CRAF activation (Garnett et al., 2005). Since RAS and CRAF are required for ERK activation by PLX4720 and 885-A, we investigated if these drugs induce BRAF binding to CRAF.

What is the BRAF pathway?

B-Raf protein is part of a larger mechanism called the RAS-RAF-MEK-ERK pathway. This pathway helps regulate how cells grow, multiply and survive. When any part of this pathway is overactive inside a tumor, it is helping the cancer grow and potentially spread.

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