Blot motif in ASC

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Aug 6th, 2022
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How to blot motif in ASC

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hi chris hadfield here aboard the international space station we keep busy on board the space station long days lots of work physical exercise at the end of it youamp;#39;re tired but how do you sleep in space in order to make it comfortable for the astronauts originally they were going to put us all in one habitation module with sleep stations all around it but the way a station was eventually built we have sleep stations inside node two which is in the forward part of the station and inside the service module which is in the aft a total of six small bedrooms sleep stations sleep pods inside each one is just a sleeping bag tied to the wall you might think itamp;#39;s uncomfortable not having a mattress and a pillow but without gravity of course you donamp;#39;t need anything to hold you up you can just completely relax and you donamp;#39;t even need a pillow in space you donamp;#39;t even have to hold your head up so you can relax every muscle in your body and your arms f

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ASC specks are micrometer-sized structures formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD). ASC specks are characteristic of inflammasome activation. The inflammasome adapter ASC is localized mainly in the nucleus of macrophages and monocytes.
For the activation of inflammasomes, ASC can form large oligomeric filaments to facilitate the recruitment of procaspases. Sborgi et al. applied cryo‐EM and NMR and determined that ASC assembles to long filaments in response to pathogen invasion and thus amplifies the inflammatory signal.
Apoptosis-associated speck- Apoptosis-associated speck-like protein containing a CARD (ASC) has a pivotal role in inflammasome assembly and activation. While ASC function has been primarily implicated in innate immune cells, its contribution to lymphocyte biology is unclear. The Inflammasome Adaptor ASC Intrinsically Limits CD4+ T - Frontiers Frontiers fimmu.2019.01566 full Frontiers fimmu.2019.01566 full
Results suggest that apoptosis-associated speck-like protein (ASC) can function as an adaptor molecule for Bax and regulate a p53-Bax mitochondrial pathway of apoptosis. Methylation-mediated silencing of TMS1/ASC confers a survival advantage to ovarian tumor cells.
Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis. Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like ASM Journals - American Society for Microbiology doi jvi.02667-12 ASM Journals - American Society for Microbiology doi jvi.02667-12
ASC acts as an inflammatory response-associated gene by regulating caspase-1 activation and IL-1beta and IL-6 secretion, which may correlate with its biological effects. Data indicate that ASC was phosphorylated during inflammasome activation in a Syk- and Jnk-dependent manner. Pycard PYD and CARD domain containing [ (house mouse)] - NCBI NCBI gene NCBI gene
Apoptosis associated speck like protein containing CARD (ASC) is widely researched and recognized as an adaptor protein participating in inflammasome assembly and pyroptosis. It contains a bipartite structure comprising of a pyrin and a caspase recruitment domain (CARD) domain. Comprehensive review of ASC structure and function in immune SpringerLink article SpringerLink article

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