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welcome to this overview of the Pico framework from the Health Sciences Library at the University of North Carolina at Chapel Hill this video will cover how to use the Pico framework for improved literature searching we will demonstrate its use in PubMed but you can use it in any biomedical literature database the Pico framework helps you determine which search terms you should use to find literature that answers your clinical question or will help you determine your research hypothesis the P stands for the patient or population the I stands for the intervention of interest the C stands for the comparison intervention and the O stands for your outcomes you can also add on to the standard Pico framework you can add a t for the time frame of interest a t for the types of studies that will best answer your question or an S for the setting of interest if your initial search is too broad these additions will help you more quickly find the most useful articles letamp;#39;s see how Pico work